Proving a Link Between Chronic Alcohol Exposure and Impaired Inhibitory Function

The GABAB receptor (GABABR) agonist baclofen has been used to treat alcohol and several other substance use disorders yet how exactly it works remains unclear. Professor Tifei Yuan, a Tianqiao and Chrissy Chen Institute for Translational Research project lead and Principal Investigator at Shanghai Mental Health Center recently published an online paper titled, “Reduced Motor Cortex GABABR Function Following Chronic Alcohol Exposure” in the journal Molecular Psychiatry which shows progress understanding the study of the neural mechanisms of alcohol addiction and how it can lead to increased impulsive behavior . This research was supported by the Tianqiao and Chrissy Chen Institute for Translational Research.

Read the article in Molecular Psychiatry