Meeting Report: NeuroFrance 2023 Marc Oudart Thesis Report

Summary

The aim of my thesis project was to study the local regulation of translation in astrocytes, as a mechanism for cell polarity, which by enabling long and branched processes that contact synapses (perisynaptic astrocytic processes (PAP)) and blood vessels (perivascular astrocytic processes (PvAP)) could regulate physiological functions in the brain.

To reach this aim, I identified proteins associated with astrocytic polysomes that potentially regulate translation, including the RACK1 protein. My work shows that RACK1 is preferentially associated with the Kcnj10 mRNA encoding the KIR4.1 potassium channel.

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